Nature as blueprint: Global phenotype engineering of CHO production cells based on a multi-omics comparison with plasma cells

Author:

Raab NadjaORCID,Zeh Nikolas,Kretz Robin,Weiß Linus,Stadermann Anna,Lindner Benjamin,Fischer Simon,Stoll Dieter,Otte Kerstin

Funder

Ministerium für Wissenschaft Forschung und Kunst Baden-Württemberg

Bundesministerium fur Bildung und Forschung Dienststelle Berlin

Bundesministerium für Bildung und Forschung

Publisher

Elsevier BV

Reference64 articles.

1. Strategies and considerations for improving expression of “difficult to express” proteins in CHO cells;Alves,2017

2. Inhibition of endogenous miR‐23a/miR‐377 in CHO cells enhances difficult‐to‐express recombinant lysosomal sulfatase activity;Amadi;Biotechnol. Prog.,2020

3. Genetic engineering approaches to improve posttranslational modification of biopharmaceuticals in different production platforms;Amann;Biotechnol. Bioeng.,2019

4. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing;Becker;J. Biotechnol.,2011

5. Two new interleukin-6 dependent plasma cell lines carrying a chromosomal abnormality involving the IL-6 gene locus;Burger;Br. J. Haematol.,1994

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