Predicting Drug-Drug Interactions Involving Multiple Mechanisms Using Physiologically Based Pharmacokinetic Modeling: A Case Study With Ruxolitinib

Author:

Shi JG1,Fraczkiewicz G2,Williams WV1,Yeleswaram S1

Affiliation:

1. Incyte Corporation; Wilmington Delaware USA

2. Simulations Plus, Inc.; Lancaster California USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference28 articles.

1. Drug interactions evaluation: an integrated part of risk assessment of therapeutics;Zhang;Toxicol. Appl. Pharmacol.,2010

2. US Food and Drug Administration Draft guidance for industry: drug interaction studies - study design, data analysis, and implications for dosing and labeling http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm292362.pdf 2012

3. European Medicines Agency Guideline on the investigation of drug interactions http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/07/WC500129606.pdf 2012

4. Evaluation of various static in vitro-in vivo extrapolation models for risk assessment of the CYP3A inhibition potential of an investigational drug;Vieira;Clin. Pharmacol. Ther.,2014

5. vitro prediction of clinical drug interactions with CYP3A substrates: we are not there yet;Greenblatt;Clin. Pharmacol. Ther.,2014

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