Predicting Drug-Drug Interactions Involving Multiple Mechanisms Using Physiologically Based Pharmacokinetic Modeling: A Case Study With Ruxolitinib
Author:
Affiliation:
1. Incyte Corporation; Wilmington Delaware USA
2. Simulations Plus, Inc.; Lancaster California USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Reference28 articles.
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3. European Medicines Agency Guideline on the investigation of drug interactions http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/07/WC500129606.pdf 2012
4. Evaluation of various static in vitro-in vivo extrapolation models for risk assessment of the CYP3A inhibition potential of an investigational drug;Vieira;Clin. Pharmacol. Ther.,2014
5. vitro prediction of clinical drug interactions with CYP3A substrates: we are not there yet;Greenblatt;Clin. Pharmacol. Ther.,2014
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