Application of metabolic modeling for targeted optimization of high seeding density processes-Reference-Cited by-同舟云学术

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Application of metabolic modeling for targeted optimization of high seeding density processes

Published:2021-03 Issue:5 Volume:118 Page:1793-1804
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotech & Bioengineering

Author:

Brunner Matthias¹^ORCID,Kolb Klara¹,Keitel Alena¹,Stiefel Fabian¹,Wucherpfennig Thomas¹,Bechmann Jan¹,Unsoeld Andreas¹,Schaub Jochen¹

Affiliation:

1. Bioprocess Development Biologicals Boehringer Ingelheim Pharma GmbH & Co. KG Biberach Germany

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27693

Reference41 articles.

1. Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry

2. Multi‐Omics Study on the Impact of Cysteine Feed Level on Cell Viability and mAb Production in a CHO Bioprocess

3. Perfusion cultures require optimum respiratory ATP supply to maximize cell‐specific and volumetric productivities

4. Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review

5. Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

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1. Stepwise cell culture process intensification for high-productivity and cost-effective commercial manufacturing of a Mabcalin™ bispecifics;Biochemical Engineering Journal;2024-11

2. Building blocks needed for mechanistic modeling of bioprocesses: A critical review based on protein production by CHO cells;Metabolic Engineering Communications;2024-06

3. Technoeconomic Analysis of Intensified PEGylated Biopharmaceutical Recombinant Protein Production: Alpha Antitrypsin as a Model Case;Processes;2024-05-10

4. Deciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computational Modeling Perspective;Bioengineering;2024-03-28

5. Amino acid degradation pathway inhibitory by‐products trigger apoptosis in CHO cells;Biotechnology Journal;2024-02

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