Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response

Author:

Temko Daniel123,Van Gool Inge C4,Rayner Emily5,Glaire Mark5,Makino Seiko5,Brown Matthew5,Chegwidden Laura5,Palles Claire5,Depreeuw Jeroen678,Beggs Andrew9ORCID,Stathopoulou Chaido5,Mason John5,Baker Ann-Marie1,Williams Marc110,Cerundolo Vincenzo11,Rei Margarida11,Taylor Jenny C5,Schuh Anna12,Ahmed Ahmed1314,Amant Frédéric15,Lambrechts Diether78,Smit Vincent THBM4,Bosse Tjalling4ORCID,Graham Trevor A1ORCID,Church David N5ORCID,Tomlinson Ian9

Affiliation:

1. Evolution and Cancer Laboratory, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry; Queen Mary University of London; London UK

2. Centre for Maths and Physics in the Life Sciences and Experimental Biology (CoMPLEX); University College London; London UK

3. Department of Computer Science; University College London; London UK

4. Department of Pathology; Leiden University Medical Centre; Leiden The Netherlands

5. Wellcome Trust Centre for Human Genetics; University of Oxford; Oxford UK

6. KU Leuven (University of Leuven), University Hospitals Leuven, Department of Obstetrics and Gynaecology; Division of Gynaecological Oncology; Leuven Belgium

7. KU Leuven, Department of Human Genetics; Laboratory for Translational Genetics; Leuven Belgium

8. VIB Centre for Cancer Biology; Laboratory for Translational Genetics; Leuven Belgium

9. Institute of Cancer and Genomic Sciences; University of Birmingham; Birmingham UK

10. Department of Cell and Developmental Biology; University College London; London UK

11. MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine; University of Oxford; Oxford UK

12. Department of Oncology; University of Oxford; Oxford UK

13. Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine; University of Oxford; Oxford UK

14. Nuffield Department of Obstetrics & Gynaecology; University of Oxford; Oxford UK

15. Centre for Gynaecological Oncology Amsterdam; Netherlands Cancer Institute; Amsterdam The Netherlands

Funder

Academy of Medical Sciences

Cancer Research UK

Department of Health, Australian Government

Fonds Wetenschappelijk Onderzoek

FP7 Health

H2020 European Research Council

Health Foundation

KWF Kankerbestrijding

Medical Research Council Canada

Ovarian Cancer Action

National Institute for Health Research (NIHR) Oxford Biomedical Research Centre

Wellcome Trust

Publisher

Wiley

Subject

Pathology and Forensic Medicine

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