Clonal status of actionable driver events and the timing of mutational processes in cancer evolution-Reference-Cited by-同舟云学术

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

Published:2015-04-15 Issue:283 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

McGranahan Nicholas¹²,Favero Francesco³,de Bruin Elza C.⁴,Birkbak Nicolai Juul¹³⁴,Szallasi Zoltan³⁵,Swanton Charles¹⁴

Affiliation:

1. Cancer Research UK London Research Institute, London WC2A 3LY, UK.

2. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London WC1E 6BT, UK.

3. Cancer System Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark.

4. UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O’Gorman Building, Huntley Street, London WC1E 6DD, UK.

5. Children’s Hospital Informatics Program, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Pan-cancer analysis of tumor subclonal structures uncovers widespread intratumor heterogeneity in actionable driver events and reveals mutational processes fueling their selection.

Funder

Prostate Cancer Foundation

Breast Cancer Research Foundation

EU FP7

Cancer Research UK

European Research Council (THESEUS)

Rosetrees Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference45 articles.