Affiliation:
1. School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 China
2. Joint International Research Laboratory of Agriculture & Agri-Product Safety of Ministry of Education of China Yangzhou University Yangzhou 225009 China
Abstract
AbstractViburnum luzonicum is widely distributed in China. Its branch extracts showed potential α‐amylase and α‐glucosidase inhibitory activities. In order to discover new bioactive constituents, five undescribed phenolic glycosides, viburozosides A−E (1–5), were obtained by bioassay‐guided isolation coupled with HPLC‐QTOF‐MS/MS analysis. Their structures were elucidated by spectroscopic analyses, including 1D NMR, 2D NMR, ECD, and ORD. All compounds were tested for their α‐amylase and α‐glucosidase inhibitory potency. Compound 1 showed significantly competitive inhibition against α‐amylase (IC50=17.5 μM) and α‐glucosidase (IC50=13.6 μM).
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering