Chemical Composition of Extracts and Fractions from <i>Miconia Ibaguensis</i> (Melastomataceae) Leaves and Evaluation of Biological Activities-Reference-Cited by-同舟云学术

Chemical Composition of Extracts and Fractions from Miconia Ibaguensis (Melastomataceae) Leaves and Evaluation of Biological Activities

Published:2024-06-22 Issue:7 Volume:21 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Sehnem Gabriela S.¹,Silva Julia A.¹^ORCID,da C. Silva Tiara¹^ORCID,Prado Diego G.¹^ORCID,Santiago Mariana B.²^ORCID,O. Santos Anna Lívia²,Martins Mário M.³^ORCID,Cunha Luis C. S.⁴^ORCID,Sousa Raquel M. F.¹^ORCID,Romero Rosana⁵^ORCID,Bittar Vinicius P.⁶,Borges Ana Luiza S.⁶,Martins Carlos H. G.²^ORCID,Espindola Foued S.⁶^ORCID,de Oliveira Alberto¹^ORCID

Affiliation:

1. Nucleus of Research in Natural Products, Institute of Chemistry Federal University of Uberlândia – MG Uberlândia Brazil

2. Antimicrobial Testing Laboratory, Institute of Biomedical Sciences Universidade Federal de Uberlândia – MG Uberlândia Brazil

3. Laboratory of Nanobiotechnology Institute of Biotechnology Federal University of Uberlândia – MG Uberlândia Brazil

4. Bioprospecting Center for Natural Products, Chemistry Department Federal Institute of Triângulo Mineiro – MG Uberaba Brazil

5. Institute of Biology Federal University of Uberlândia – MG Uberlândia Brazil

6. Laboratory of Biochemistry and Molecular Biology, Institute of Biotechnology Federal University of Uberlândia – MG Uberlândia Brazil

Abstract

AbstractThe study aimed to assess the chemical composition of Miconia ibaguensis leaves extracts and fractions obtained from the ethanolic extract (EE), along with evaluating their antifungal, antibacterial, antidiabetic, and antioxidant activities. The ethyl acetate fraction (EAF) exhibited potent antifungal activity against Candida spp (1.95–3.90 μg mL−1) and potent antioxidant activity in the DPPH (1.74±0.07 μg mL−1), FRAP (654.01±42.09 μmol ETrolox/gsample), and ORAC (3698.88±37.28 μmol ETrolox/gsample) methods. The EE displayed inhibition against the α‐amylase enzyme (8.42±0.05 μg mL−1). Flavonoids, hydrolysable tannins, triterpenoids, and phenolic acids, identified in the EE and fractions via (−)‐HPLC‐ESI‐MS/MS analysis, were found to contribute to the species′ biological activity potentially. These findings suggest promising avenues for further research and potential applications in pharmacology and natural products, offering new possibilities in the fight against global health issues.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202400680

Reference60 articles.

1. Taxonomia de Melastomataceae no Brasil: retrospectiva, perspectivas e chave de identificação para os gêneros

2. Caracterização morfoanatômica de folhas e caules de Microlicia hatschbachii Wurdack, Melastomataceae

3. An Overview of Miconia Genus: Chemical Constituents and Biological Activities

4. The Genus Miconia Ruiz & Pav. (Melastomataceae): Ethnomedicinal Uses, Pharmacology, and Phytochemistry

5. Health functions and related molecular mechanisms of Miconia genus: A systematic review