Affiliation:
1. School of Chemistry and Chemical Engineering Yunnan Normal University Kunming 650050 P. R. China
2. Medical Research Center The Affiliated Hospital of Qingdao University Qingdao 266003 China
Abstract
AbstractSeven lignans were isolated from 70 % aqueous acetone extracts of the twigs and leaves of Horsfieldia kingii. Among these, new compounds 1–3 were identified by spectroscopic techniques, with horsfielenigans A and B (1 and 2) being particularly noteworthy for their rare β‐benzylnaphthalene skeleton, where compound 1 contains an oxabicyclo[3,2,1]octane moiety. In vitro evaluation of bioactivity against nitric oxide (NO) production in LPS‐activated RAW264.7 macrophages revealed inhibitory effects by 1 (IC50=7.3 μM) and 2 (IC50=9.7 μM).
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
2 articles.
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