Anti‐Inflammatory and Antioxidant Effects of Rosmarinic Acid Trimetallic (Cu0.5Zn0.5Fe2O4) Nanoparticles

Author:

Imraish Amer1ORCID,Zihlif Malek2,Abu Thiab Tuqa1,Al‐Awaida Wajdy3,Al‐Ameer Hamzeh J.4,Abu‐Irmaileh Basha'er5,Al‐Hunaiti Afnan6

Affiliation:

1. Department of Biological Sciences School of Science The University of Jordan Queen Rania Al-Abdullah Street Amman 11942 Jordan

2. Department of Pharmacology School of Medicine The University of Jordan Queen Rania Al-Abdullah Street Amman 11942 Jordan

3. Department of Biology and Biotechnology Faculty of Science American University of Madaba P.O. Box: 99 Madaba 17110 Jordan

4. Department of Biotechnology Faculty of Allied Medical Sciences Al-Ahliyya Amman University (AAU) Amman 19328 Jordan

5. Hamdi Mango Centre for Scientific Research The University of Jordan Queen Rania Al-Abdullah Street Amman 11942 Jordan

6. Department of Chemistry School of Science The University of Jordan Queen Rania Al-Abdullah Street Amman 11942 Jordan

Abstract

AbstractNewly, green metallic‐nanoparticles (NPs) have received scientists’ interest due to their wide variable medicinal applications owned to their economical synthesis and biologically compatible nature. In this study, we used rosmarinic acid (RosA) to prepare Cu0.5Zn0.5FeO4 NPs and later encapsulated them using PEG polymer. Characterization of NPs was done using the XRD method and SEM imaging. Further, we explored the encapsulated NPs for anti‐inflammatory properties by downregulating the expression of pro‐inflammatory cytokines mRNA in LPS‐stimulated Raw 264.7 cells. Besides, employing DPPH, NO and ABTS radical scavenging assays to examine the antioxidant activity of the synthesized Cu0.5Zn0.5FeO4 NPs. Cu0.5Zn0.5FeO4 NPs revealed moderate antioxidant activity by scavenging DPPH and nitric oxide. We demonstrated that the NPs showed high potential anti‐inflammatory activity by suppressing the mRNA and protein levels of pro‐inflammatory cytokines in a dose‐dependent manner, in LPS‐induced Raw 264.7 cells. To our best knowledge, this is the first report where RosA was found to be a suitable phyto source for the green synthesis of Cu0.5Zn0.5FeO4 NPs and their in vitro anti‐inflammatory and antioxidant effects. Taken together, our findings suggest that the RosA is a green resource for the eco‐friendly synthesis of Cu0.5Zn0.5FeO4/PEG NPs, which further can be employed as a novel anti‐inflammatory therapeutic agent.

Publisher

Wiley

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