Affiliation:
1. Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and Energy South China Agricultural University Guangzhou 510642 China
2. Key Laboratory of Molecular Target & Clinical Pharmacology School of Pharmaceutical Sciences and the Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 China
Abstract
AbstractFour new isocoumarins, alternariethers A–C (1–3) and alternariester (4) were separated from the fermentation of the fungus Alternaria malorum FL39, purified from Myoporum bontioides. Their structures were ascertained using NMR and HR‐ESI‐MS spectroscopy. For compound 4, the absolute configuration was solved with the help of ECD calculation and the DP4+ method. Compared with the positive control triadimefon, compound 1 showed more potent antifungal effects on Colletotrichum musae. The antifungal effects of compounds 1, 2, and 3 on Fusarium oxysporum and Fusarium graminearum, of compound 4 on F. oxysporum, were equal to those of triadimefon. Except for compound 4 which was inactive against Escherichia coli with O78 serotype, all compounds showed moderate or weak antibacterial activity against Staphylococcus aureus ATCC 6538 and E. coli with O6 or O78 serotype.
Funder
Basic and Applied Basic Research Foundation of Guangdong Province