The human NMDA receptor GluN2A N615K variant influences channel blocker potency-Reference-Cited by-同舟云学术

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The human NMDA receptor GluN2A N615K variant influences channel blocker potency

Published:2019-06-20 Issue:4 Volume:7 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Marwick Katie F. M.¹^ORCID,Skehel Paul A.¹,Hardingham Giles E.¹²³,Wyllie David J. A.¹²⁴^ORCID

Affiliation:

1. Centre for Discovery Brain Sciences Hugh Robson Building, University of Edinburgh Edinburgh UK

2. Simons Initiative for the Developing Brain, Hugh Robson Building University of Edinburgh Edinburgh UK

3. UK Dementia Research Institute University of Edinburgh Edinburgh UK

4. Centre for Brain Development and Repair Institute for Stem Cell Biology and Regenerative Medicine Bangalore India

Funder

Wellcome Trust

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.495

Reference21 articles.

1. Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

2. Magnesium gates glutamate-activated channels in mouse central neurones

3. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

4. GRIN2A mutation and early‐onset epileptic encephalopathy: personalized therapy with memantine

5. Influence of GluN2 subunit identity on NMDA receptor function

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1. Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology;Physiological Research;2024-08-31

2. Memantine: Updating a rare success story in pro-cognitive therapeutics;Neuropharmacology;2024-02

3. Differential responses of disease‐related GRIN variants located in pore‐forming M2 domain of N‐methyl‐D‐aspartate receptor to FDA‐approved inhibitors;Journal of Neurochemistry;2023-08-30

4. Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory;Molecular Psychiatry;2022-04-28

5. Opportunities for Precision Treatment of GRIN2A and GRIN2B Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors;Journal of Pharmacology and Experimental Therapeutics;2022-02-02

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