Opportunities for Precision Treatment of <i>GRIN2A</i> and <i>GRIN2B</i> Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors-Reference-Cited by-同舟云学术

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Opportunities for Precision Treatment of GRIN2A and GRIN2B Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors

Published:2022-02-02 Issue:1 Volume:381 Page:54-66
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Han Wei,Yuan Hongjie,Allen James P.,Kim Sukhan,Shaulsky Gil H.,Perszyk Riley E.,Traynelis Stephen F.,Myers Scott J.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference51 articles.

1. NMDA Di-Heteromeric Receptor Populations and Associated Proteins in Rat Hippocampus

2. Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice

3. Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome;Auvin;Ann Clin Transl Neurol,2020

4. Clinical and therapeutic significance of genetic variation in the GRIN gene family encoding NMDARs

5. Identification and Characterization of Novel NMDA Receptor Antagonists Selective for NR2A- over NR2B-Containing Receptors

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1. Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology;Physiological Research;2024-08-31

2. Rescuing tri-heteromeric NMDA receptor function: the potential of pregnenolone-sulfate in loss-of-function GRIN2B variants;Cellular and Molecular Life Sciences;2024-05-25

3. Distances from ligands as main predictive features for pathogenicity and functional effect of variants in NMDA receptors;2024-05-07

4. De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor;Cellular and Molecular Life Sciences;2024-03-28

5. Radiprodil, a selective GluN2B negative allosteric modulator, rescues audiogenic seizures in mice carrying the GluN2A(N615S) mutation;British Journal of Pharmacology;2024-03-26

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