Increased replication capacity following evolution of PYxE insertion in Gag-p6 is associated with enhanced virulence in HIV-1 subtype C from East Africa

Author:

Aralaguppe Shambhu G.1,Winner Dane2,Singh Kamalendra3,Sarafianos Stefan G.3,Quiñones-Mateu Miguel E.24,Sönnerborg Anders15,Neogi Ujjwal1

Affiliation:

1. Division of Clinical Microbiology; Department of Laboratory Medicine; Karolinska Institute; Stockholm Sweden

2. University Hospital Translational Laboratory; University Hospitals Case Medical Center; Cleveland Ohio

3. Department of Molecular Microbiology and Immunology; Christopher Bond Life Sciences Center; University of Missouri; Columbia Missouri

4. Department of Pathology; Case Western Reserve University; Cleveland Ohio

5. Unit of Infectious Diseases; Department of Medicine Huddinge; Karolinska Institute; Stockholm Sweden

Funder

Karolinska Institutet Research Foundation

Swedish Physicians Against AIDS Research Foundation

Swedish Research Council

Stockholm County Council

CWRU/UH Center for AIDS Research

University of Missouri

Publisher

Wiley

Subject

Infectious Diseases,Virology

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