Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective-Reference-Cited by-同舟云学术

Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective

Published:2014-03-21 Issue:6177 Volume:343 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fraser Christophe¹,Lythgoe Katrina¹,Leventhal Gabriel E.²,Shirreff George²,Hollingsworth T. Déirdre³⁴⁵,Alizon Samuel⁶,Bonhoeffer Sebastian²

Affiliation:

1. Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London SW7 2AZ, UK.

2. Institute for Integrative Biology, Eidgenössische Technische Hochschule Zurich, Zurich 8092, Switzerland.

3. Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK.

4. School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.

5. Department of Clinical Sciences, Liverpool School of Tropical Medicine (LSTM), Pembroke Place, Liverpool, L3 5QA, UK.

6. Laboratoire Maladies Infectieuses et Vecteurs Écologie, Génétique, Évolution et Contrôle, UMR CNRS 5290, Institut pour la Recherche et le Développement (IRD), UM1, UM2, Montpellier 34394, France.

Abstract

HIV Virulence A major focus of research on HIV is on host responses to infection—understandably, because the virus targets the immune system and because of the interest in vaccine development. In reviewing what little research has been done on viral virulence determinants, Fraser et al. ( 10.1126/science.1243727 ) present evolutionary explanations for some of the poorly understood phenomena that mark HIV infection, including long-term survivorship, latency, rapid within-host evolution, and inheritability of between-host virulence.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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