Genetic rearrangement during site specific integration event facilitates cell line development of a bispecific molecule-Reference-Cited by-同舟云学术

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Genetic rearrangement during site specific integration event facilitates cell line development of a bispecific molecule

Published:2021-05-12 Issue: Volume: Page:
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Tevelev Barbara¹^ORCID,Patel Himakshi²,Shields Kathleen²,Wei Wei¹,Cooley Cecilia¹,Zhang Sam¹,Bitzas Gabrielle³,Duan Weili³,Khetemenee Lam³,Jackobek Ryan³,D'Antona Aaron³,Sievers Annette³,King Amy³,Tam Amy³,Zhang Yan³,Sousa Eric³,Cohen Justin³,Wroblewska Lila³,Marshall Jeffrey²,Jackson Martha²,Scarcelli John J.¹^ORCID

Affiliation:

1. Cell Line Development Biotherapeutics Pharmaceutical Sciences, Pfizer Inc. Andover Massachusetts USA

2. Analytical Research and Development Biotherapeutics Pharmaceutical Sciences, Pfizer Inc. Andover Massachusetts USA

3. BioMedicine Design, Pfizer Inc. Andover Massachusetts USA

Publisher

Wiley

Subject

Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.3158

Reference30 articles.

1. Cell culture processes for monoclonal antibody production;Li F;MAbs,2010

2. CHO cells in biotechnology for production of recombinant proteins: current state and further potential;Kim JY;Appl Microbiol Biotechnol,2012

3. Transient CHO expression platform for robust antibody production and its enhanced N‐glycan sialylation on therapeutic glycoproteins;Zhong X;Biotechnol Prog,2019

4. Production of recombinant protein therapeutics in cultivated mammalian cells;Wurm FM;Nat Biotechnol,2004

5. Mammalian cell protein expression for biopharmaceutical production;Zhu J;Biotechnol Adv,2012

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1. Accelerating the speed of innovative anti-tumor drugs to first-in-human trials incorporating key de-risk strategies;mAbs;2023-12-14

2. Droplet digital PCR: A comprehensive tool for genetic analysis and prediction of bispecific antibody assembly during cell line development;New Biotechnology;2023-12

3. The impact of expression vector position on transgene transcription allows for rational expression vector design in a targeted integration system;Biotechnology Journal;2023-06-09

4. A genetic off‐target event in a site‐specific integration cell line expressing monoclonal antibody has no impact on commercial suitability;Biotechnology Progress;2023-01-19

5. An innovative platform to improve asymmetric bispecific antibody assembly, purity, and expression level in stable pool and cell line development;Biochemical Engineering Journal;2022-12

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