Affiliation:
1. Department of Applied Chemistry Graduate School of Engineering Osaka University 2‐1 Yamadaoka Suita Osaka 565‐0871 Japan
2. Research Fellow of Japan Society for the Promotion of Science Kojimachi Business Center Building 5‐3‐1 Kojimachi, Chiyoda‐ku Tokyo 102‐0083 Japan
3. Mitsubishi Chemical Corporation Science and Innovation Center 1000 Kamoshida‐cho, Aoba‐ku Yokohama Kanagawa 227‐8502 Japan
4. Mitsubishi Chemical Corporation Osaka R&D Center 13‐1 Muroyama 2‐chome Ibaraki Osaka 567‐0052 Japan
Abstract
AbstractEmbedded extrusion printing provides a versatile platform for fabricating complex hydrogel‐based biological structures with living cells. However, the time‐consuming process and rigorous storage conditions of current support baths hinder their commercial application. This work reports a novel “out‐of‐the‐box” granular support bath based on chemically crosslinked cationic polyvinyl alcohol (PVA) microgels, which is ready to use by simply dispersing the lyophilized bath in water. Notably, with ionic modification, PVA microgels yield reduced particle size, uniform distribution, and appropriate rheological properties, contributing to high‐resolution printing. Following by the lyophilization and re‐dispersion process, ion‐modified PVA baths recover to its original state, with unchanged particle size, rheological properties, and printing resolution, demonstrating its stability and recoverability. Lyophilization facilitates the long‐term storage and delivery of granular gel baths, and enables the application of “out‐of‐the‐box” support materials, which will greatly simplify experimental procedures, avoid labor‐intensive and time‐consuming operations, thus accelerating the broad commercial development of embedded bioprinting.
Subject
Materials Chemistry,Polymers and Plastics,Organic Chemistry
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献