Odanacatib Treatment Affects Trabecular and Cortical Bone in the Femur of Postmenopausal Women: Results of a Two-Year Placebo-Controlled Trial

Author:

Engelke Klaus12,Fuerst Thomas3,Dardzinski Bernard4,Kornak John5,Ather Shabana6,Genant Harry K7,de Papp Anne6

Affiliation:

1. Synarc Inc.; Hamburg Germany

2. Institute of Medical Physics; University of Erlangen; Erlangen Germany

3. Synarc Inc.; Newark CA USA

4. Department of Radiology, and Radiological Sciences; Uniformed Services University of Health Sciences (USUHS); Bethesda MD USA

5. Department of Epidemiology & Biostatistics; University of California; San Francisco CA USA

6. Merck & Co., Inc.; Whitehouse Station NJ USA

7. Department of Radiology; University of California; San Francisco CA USA

Funder

Merck & Co

ASBMR Annual Meeting

ECCEO Meeting

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference15 articles.

1. its skeletal actions and role as a therapeutic target in osteoporosis;Costa;Nat Rev Rheumatol.,2011

2. Odanacatib, a cathepsin K inhibitor for the treatment of osteoporosis and other skeletal disorders associated with excessive bone remodeling;Lewiecki;IDrugs.,2009

3. Odanacatib in the treatment of postmenopausal women with low bone mineral density: five years of continued therapy in a phase 2 study;Langdahl;J Bone Miner Res.,2012

4. Odanacatib in the treatment of postmenopausal women with low bone mineral density: three-year continued therapy and resolution of effect;Eisman;J Bone Miner Res.,2011

5. Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density;Bone;J Bone Miner Res.,2010

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