Differentiation of Aneugens and Clastogens in the In Vitro Micronucleus Test by Kinetochore Scoring Using Automated Image Analysis
Author:
Affiliation:
1. Bayer AG, Investigational Toxicology; Berlin Germany
2. Fraunhofer ITEM, Preclinical Pharmacology and In Vitro Toxicology; Hannover Germany
3. Molecular Devices; Biberach an der Riss Germany
Publisher
Wiley
Subject
Health, Toxicology and Mutagenesis,Genetics (clinical),Epidemiology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/em.22259/fullpdf
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3. Molecular cytogenetic evaluation of the mechanism of micronucleus formation induced by camptothecin, topotecan, and irinotecan;Attia;Environ Mol Mutagen,2009
4. Flow cytometric analysis of micronuclei in mammalian cell cultures: Past, present and future;Avlasevich;Mutagenesis,2011
5. Detection of environmental clastogens and aneugens in human fibroblasts by cytokinesis-blocked micronucleus assay associated with immunofluorescent staining of CENP-A in micronuclei;Benameur;Chemosphere.,2011
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1. A new imaging platform ( iScreen ) allows for the concurrent assessment of micronucleus induction and genotoxic mode of action in human A375 cells;Environmental and Molecular Mutagenesis;2022-06
2. Aneugen Versus Clastogen Evaluation and Oxidative Stress-Related Mode-of-Action Assessment of Genotoxic Compounds Using the ToxTracker Reporter Assay;Toxicological Sciences;2020-07-03
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