Using a Systems Pharmacology Model of the Blood Coagulation Network to Predict the Effects of Various Therapies on Biomarkers-Reference-Cited by-同舟云学术

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Using a Systems Pharmacology Model of the Blood Coagulation Network to Predict the Effects of Various Therapies on Biomarkers

Published:2015-06-19 Issue:7 Volume:4 Page:396-405
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Nayak S¹,Lee D²,Patel‐Hett S³,Pittman DD³,Martin SW¹,Heatherington AC²,Vicini P⁴,Hua F²

Affiliation:

1. Pharmacometrics Global Innovative Pharma Business (GIPB)Pfizer Inc.Cambridge Massachusetts USA

2. Quantitative Clinical SciencesPharmaTherapeutics Clinical R&D, Pfizer Inc.Cambridge Massachusetts USA

3. Rare Disease Research Unit Pfizer Inc.Cambridge Massachusetts USA

4. Pharmacokinetics Dynamics and MetabolismNew Biological Entities, Pfizer Inc.Cambridge Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.50

Reference39 articles.

1. Blood clotting in minimally altered whole blood

2. New Fundamentals in Hemostasis

3. The Hemophilias — From Royal Genes to Gene Therapy

4. Homozygosity for a Novel Missense Mutation in the Prothrombin Gene Causing a Severe Bleeding Disorder

5. Heterogeneity of human factor V deficiency. Evidence for the existence of antigen-positive variants

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