Mechanistic modeling of continuous capture step purification of biosimilar monoclonal antibody therapeutic

Author:

Deulgaonkar Prashant12ORCID,Bhambure Rahul12ORCID,Prasad Bhaskarjyoti3,Mishra Ashok3,Tiwari Sanjay3,Mody Rustom34

Affiliation:

1. Chemical Engineering and Process Development Division CSIR – National Chemical Laboratory Pune India

2. Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India

3. Biotechnology R&D, Lupin Limited Pune India

4. Sun Pharma R&D Sun Pharmaceutical Industries Vadodara India

Publisher

Wiley

Subject

Inorganic Chemistry,Organic Chemistry,Pollution,Waste Management and Disposal,Fuel Technology,Renewable Energy, Sustainability and the Environment,General Chemical Engineering,Biotechnology

Reference40 articles.

1. Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media

2. RadarRA LangerES 30 Years of Upstream Productivity Improvements. BioProcess International. (2015). Available:https://bioprocessintl.com/upstream‐processing/expression‐platforms/30‐years‐upstream‐productivity‐improvements/. [25 April 2021].

3. High-throughput process development for biopharmaceutical drug substances

4. Protein a chromatography at high titers

5. Economic Analysis of Batch and Continuous Biopharmaceutical Antibody Production: a Review

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