Affiliation:
1. Research and Development Verseau Therapeutics Newton MA 02466 USA
Abstract
AbstractMacrophages are multifunctional cells that are employed by the tumor to further its growth and adaptation. While tumor‐associated macrophages (TAMs) have widely diverse phenotypes, tumors coevolve with the ones that can promote tumorigenesis. Functionally, TAMs/myeloid cells constitute the largest negative influence on the tumor microenvironment and need to be reprogrammed in order to enable successful anti‐tumor response in most tumors. It is predicted that successful TAM repolarization has the potential to become a staple of immuno‐oncology across most indications.