Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Author:

Paolicelli Rosa C.1,Bolasco Giulia1,Pagani Francesca2,Maggi Laura2,Scianni Maria2,Panzanelli Patrizia3,Giustetto Maurizio34,Ferreira Tiago Alves1,Guiducci Eva1,Dumas Laura1,Ragozzino Davide2,Gross Cornelius T.1

Affiliation:

1. Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Via Ramarini 32, 00015 Monterotondo, Italy.

2. Pasteur Institute, Foundation Cenci Bolognetti, and Department of Human Physiology and Pharmacology, Center of Excellence BEMM, University of Rome, La Sapienza, Piazzale Aldo Moro 5, 00185 Roma, Italy.

3. Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Italy.

4. National Institute of Neuroscience, 10126 Turin, Italy.

Abstract

A good brain needs a good vacuum cleaner.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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