Author:
Frangou S.,Sharma T.,Sigmundsson T.,Barta P.,Pearlson G.,Murray R. M.
Abstract
BackgroundLoss or reversal of the normal asymmetry of the planum temporale (PT) has been reported in schizophrenia, and may be due to aberrations in the gene(s) controlling the development of brain asymmetries. We tested this hypothesis in a sample of schizophrenics and their relatives from families multiply affected with the disorder.MethodWe compared 32 schizophrenics and 55 of their non-schizophrenic first-degree relatives with 39 matched community controls. Volumetric measurements of the cortical volume beneath the PT were obtained using the Cavalieri method from three-dimensionally reconstructed magnetic resonance imaging images.ResultsPT volume asymmetry coefficients from patients and their relatives did not differ significantly from those of the controls. Gender-specific analysis did not reveal any differences.ConclusionsAbnormalities in PT volume asymmetry are not present in familial schizophrenia, where genetic factors appear to predominate.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
86 articles.
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