A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains

Author:

Ranlund Siri12ORCID,Calafato Stella1,Thygesen Johan H.1,Lin Kuang23,Cahn Wiepke4,Crespo-Facorro Benedicto56,de Zwarte Sonja M.C.4,Díez Álvaro17,Di Forti Marta2,Iyegbe Conrad2,Jablensky Assen8,Jones Rebecca1,Hall Mei-Hua9,Kahn Rene4,Kalaydjieva Luba10,Kravariti Eugenia2,McDonald Colm11,McIntosh Andrew M.1213,McQuillin Andrew1,Picchioni Marco2,Prata Diana P.214,Rujescu Dan1516,Schulze Katja2,Shaikh Madiha1718,Toulopoulou Timothea2192021,van Haren Neeltje4,van Os Jim222,Vassos Evangelos2,Walshe Muriel12,Lewis Cathryn2,Murray Robin M.2,Powell John2,Bramon Elvira1223, , ,

Affiliation:

1. Division of Psychiatry; University College London; London UK

2. Institute of Psychiatry Psychology and Neuroscience at King's College London and South London; Maudsley NHS Foundation Trust; London UK

3. Nuffield Department of Population Health; University of Oxford; Oxford UK

4. Department of Psychiatry, Brain Centre Rudolf Magnus; University Medical Center Utrecht; Utrecht The Netherlands

5. CIBERSAM; Centro Investigación Biomédica en Red Salud Mental; Madrid Spain

6. Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine; University of Cantabria-IDIVAL; Santander Spain

7. Laboratory of Cognitive and Computational Neuroscience-Centre for Biomedical Technology (CTB); Complutense University and Technical University of Madrid; Madrid Spain

8. Centre for Clinical Research in Neuropsychiatry; The University of Western Australia; Perth, Western Australia Australia

9. Psychosis Neurobiology Laboratory, Harvard Medical School; McLean Hospital; Belmont Massachusetts

10. Harry Perkins Institute of Medical Research and Centre for Medical Research; The University of Western Australia; Perth Australia

11. The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre; National University of Ireland Galway; Galway Ireland

12. Division of Psychiatry, University of Edinburgh; Royal Edinburgh Hospital; Edinburgh UK

13. Centre for Cognitive Ageing and Cognitive Epidemiology; University of Edinburgh; Edinburgh UK

14. Faculdade de Medicina, Instituto de Medicina Molecular; Universidade de Lisboa; Portugal

15. Department of Psychiatry; Ludwig-Maximilians University of Munich; Munich Germany

16. Department of Psychiatry, Psychotherapy and Psychosomatics; University of Halle Wittenberg; Halle Germany

17. North East London Foundation Trust; London UK

18. Research Department of Clinical, Educational and Health Psychology; University College London; London UK

19. Department of Psychology, Bilkent University; Main Campus; Bilkent, Ankara Turkey

20. Department of Psychology; The University of Hong Kong, Pokfulam Rd; Hong Kong SAR China

21. The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong; The Hong Kong Jockey Club Building for Interdisciplinary Research; Hong Kong SAR China

22. Department of Psychiatry and Psychology, Maastricht University Medical Centre; EURON; Maastricht The Netherlands

23. Institute of Cognitive Neuroscience; University College London; London UK

Funder

Wellcome Trust

Medical Research Council

Dutch Health Research Council (ZON-MW)

Instituto de Salud Carlos III

SENY Fundació

Fundacion Ramón Areces and Fundacion Marqués de Valdecilla

University College London

British Medical Association

National Institute for Health Research

Psychiatry Research Trust

Schizophrenia Research Fund

Wellcome Trust Research Training Fellowship

South London and Maudsley NHS Foundation Trust

Brain and Behaviour Research Foundation's (NARSAD's) Young Investigator Award

European Research Council

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Psychiatry and Mental health,Genetics(clinical)

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