Author:
Borgwardt Stefan J.,McGuire Philip K.,Aston Jacqueline,Berger Gregor,Dazzan Paola,Gschwandtner Ute,Pflüger Marlon,D'Souza Marcus,Radue Ernst-Wilhelm,Riecher-Rössler Anita
Abstract
BackgroundNeuroanatomical abnormalities are a well-established feature of
schizophrenia. However, the timing of their emergence and the extent to
which they are related to vulnerability to the disorder as opposed to
psychotic illness itself is unclearAimsTo assess regional grey matter volume in the at-risk individuals who
subsequently developed psychosisMethodMagnetic resonance imaging data from at-risk individuals who developed
psychosis (n = 12) within the following 25 months were
compared with data from healthy volunteers (n=22) and
people with first-episode psychosis (n=25)ResultsCompared with healthy volunteers, individuals who subsequently developed
psychosis had smaller grey matter volume in the posterior cingulate
gyrus, precuneus, and paracentral lobule bilaterally and in the left
superior parietal lobule, and greater grey matter volume in a left
parietal/posterior temporal region. Compared with first-episode patients,
they had relatively greater grey matter volume in the temporal gyrus
bilaterally and smaller grey matter volume in the right lentiform
nucleusConclusionsSome of the structural brain abnormalities in individuals with an at-risk
mental state may be related to an increased vulnerability to psychosis,
while others are associated with the development of a psychotic
illness
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
130 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献