Author:
Ivanov D.,Kirov G.,Norton N.,Williams H. J.,Williams N. M.,Nikolov I.,Tzwetkova R.,Stambolova S. M.,Murphy K. C.,Toncheva D.,Thapar A.,O'Donovan M. C.,Owen M. J.
Abstract
BackgroundVelo-cardio-facial syndrome (VCFS) is associated with interstitial deletions of chromosome 22q11. About 30% of patients with VCFS have psychosis, and the rate of these deletions in schizophrenia has been reported to be about 1%. Even higher rates of VCFS deletions have been reported for childhood-onset schizophrenia.AimsTo test the hypothesis that there is an increased rate of VCFS among patients with early-onset psychosis (age at onset < 18 years). We screened 192 early-onset patients and 329 patients with adult-onset schizophrenia.MethodWe genotyped the patients and 444 healthy controls for hemizygosity of five microsatellite markers and one single nucleotide polymorphism that map to the 22q11-deleted region.ResultsOne patient had a VCFS deletion, confirmed with semi-quantitative polymerase chain reaction. None of the controls showed a pattern of genotypes consistent with hemizygosity.ConclusionsVCFS may be less frequent among patients with psychosis than previously suggested; this rate is not increased among early-onset patients.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
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