Author:
Chan Stella W. Y.,Norbury Ray,Goodwin Guy M.,Harmer Catherine J.
Abstract
BackgroundDepression is associated with neural abnormalities in emotional processing.AimsThis study explored whether these abnormalities underlie risk for depression.MethodWe compared the neural responses of volunteers who were at high and low-risk for the development of depression (by virtue of high and low neuroticism scores; high-N group and low-N group respectively) during the presentation of fearful and happy faces using functional magnetic resonance imaging (fMRI).ResultsThe high-N group demonstrated linear increases in response in the right fusiform gyrus and left middle temporal gyrus to expressions of increasing fear, whereas the low-N group demonstrated the opposite effect. The high-N group also displayed greater responses in the right amygdala, cerebellum, left middle frontal and bilateral parietal gyri to medium levels of fearful v. happy expressions.ConclusionsRisk for depression is associated with enhanced neural responses to fearful facial expressions similar to those observed in acute depression.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
101 articles.
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