Inverse agonism: the classic concept of GPCRs revisited [Review]
Author:
Affiliation:
1. Department of Endocrinology and Nephrology, The University of Tokyo School of Medicine, Tokyo 113-8655, Japan
2. Department of Pharmacology, St. Marianna University, Kawasaki 216-8511, Japan
Publisher
Japan Endocrine Society
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Link
https://www.jstage.jst.go.jp/article/endocrj/63/6/63_EJ16-0084/_pdf
Reference59 articles.
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3. 3. Oldham WM, Hamm HE (2008) Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol 9 (1): 60-71.
4. 4. Iiri T, Farfel Z, Bourne HR (1998) G-protein diseases furnish a model for the turn-on switch. Nature 394: 35-38.
5. 5. Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, et al. (2011) Conformational changes in the G protein Gs induced by the beta2 adrenergic receptor. Nature 477 (7366): 611-615.
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