Affiliation:
1. Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India
Abstract
Abstract
This study was designed to examine the impact of a principal component of hot red peppers and chilli peppers, capsaicin, on alterations in lipid peroxidation, membrane-bound enzyme profiles and glycoprotein levels during benzo(a)pyrene (BP)-induced lung cancer in Swiss albino mice. BP (50 mgkg−1) induced deleterious changes that were revealed by alterations in lipid peroxidation, membrane-bound enzyme (Na+/K+ATPase, Ca2+ATPase and Mg2+ATPase) activity, levels of total protein and protein-bound carbohydrate components (sialic acid, hexose, hexosamine, hexuronic acid and fucose). Pre-co-treatment with capsaicin (10 mgkg−1) restored the detrimental effects induced by BP, indicating its protective role in BP-induced lung cancer.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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