α-bisabolol Exerts Anti-inflammatory Action and Ameliorates Collagen-induced Arthritis in Rats

Abstract

Background: Development of synovial hypertrophy, articular tissue inflammation and tenderness in joints is the characteristic feature of rheumatoid arthritis. Drugs that are derived from natural sources which target inflammation with reduced side-effects receive much attention. Hence, the present study was designed to investigate the anti-arthritic effects of α-bisabolol, a natural chamomile essential oil and also an anti-inflammatory molecule on the rat model of collagen-induced arthritis (CIA). Methods: Animal model of CIA was established and orally administered with α-bisabolol (100 mg/kg) or vehicle and the pathological and inflammatory parameters were evaluated. Result: The results of the present findings indicate that α-bisabolol treatment ameliorates CIA-induced inflammation via inhibiting the proteases and inflammatory mediators suggesting that α-bisabolol may be a potential candidate against arthritis inflammations.