Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer

Author:

Khan Kabir A12ORCID,Wu Florence TH12ORCID,Cruz‐Munoz William12,Kerbel Robert S12ORCID

Affiliation:

1. Department of Medical Biophysics University of Toronto Toronto ON Canada

2. Biological Sciences Platform Sunnybrook Research Institute Toronto ON Canada

Funder

Canadian Institutes of Health Research

Canadian Cancer Society

Worldwide Cancer Research

University of Toronto

Publisher

EMBO

Subject

Molecular Medicine

Reference182 articles.

1. Tumor cell‐derived angiopoietin‐2 promotes metastasis in melanoma;Abdul Pari AA;Cancer Res,2020

2. Abstract 4492: Blockade of angiopoietin‐2 or Tie2 is equally effective at inhibiting tumor growth and reducing tumor vessel density in most human tumor xenograft models;Adler AP;Cancer Res,2014

3. Bevacizumab in stage II‐III colon cancer: 5‐year update of the National Surgical Adjuvant Breast and Bowel Project C‐08 trial;Allegra CJ;J Clin Oncol,2013

4. Combined antiangiogenic and anti–PD‐L1 therapy stimulates tumor immunity through HEV formation;Allen E;Sci Transl Med,2017

5. Efficacy of trebananib (AMG 386) in treating epithelial ovarian cancer;Al Wadi K;Expert Opin Pharmacother,2016

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