Author:
Ackermann Maximilian,Werlein Christopher,Plucinski Edith,Leypold Sophie,Kühnel Mark P.,Verleden Stijn E.,Khalil Hassan A.,Länger Florian,Welte Tobias,Mentzer Steven J.,Jonigk Danny D.
Abstract
AbstractIn European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis to lung regeneration, remodeling and disease progression has been increasingly appreciated. The vascular supply of the lung shows the peculiarity of dual perfusion of the pulmonary circulation (vasa publica), which maintains a functional blood-gas barrier, and the bronchial circulation (vasa privata), which reveals a profiled capacity for angiogenesis (namely intussusceptive and sprouting angiogenesis) and alveolar-vascular remodeling by the recruitment of endothelial precursor cells. The aim of this review is to outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, COPD, lung fibrosis, pulmonary hypertension and lung cancer.
Funder
National Institutes of Health
Chan Zuckerberg Initiative,United States
HORIZON EUROPE European Research Council
Deutsche Forschungsgemeinschaft
Universitätsklinikum RWTH Aachen
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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