The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib-Reference-Cited by-同舟云学术

The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib

Published:2022-06-13 Issue:7 Volume:14 Page:
ISSN:1757-4676
Container-title:EMBO Molecular Medicine
language:en
Short-container-title:EMBO Mol Med

Author:

Kobialka Piotr¹^ORCID,Sabata Helena¹^ORCID,Vilalta Odena¹,Gouveia Leonor¹²^ORCID,Angulo‐Urarte Ana¹,Muixí Laia¹,Zanoncello Jasmina¹,Muñoz‐Aznar Oscar³,Olaciregui Nagore G³,Fanlo Lucia⁴,Esteve‐Codina Anna⁵⁶,Lavarino Cinzia³,Javierre Biola M⁴,Celis Veronica⁷,Rovira Carlota⁸,López‐Fernández Susana⁹,Baselga Eulàlia¹⁰^ORCID,Mora Jaume³⁷^ORCID,Castillo Sandra D¹^ORCID,Graupera Mariona¹¹¹^ORCID

Affiliation:

1. Endothelial Pathobiology and Microenvironment Josep Carreras Leukaemia Research Institute Barcelona Spain

2. Department of Immunology, Genetics, and Pathology Uppsala University Uppsala Sweden

3. Developmental Tumor Biology Laboratory Institut de Recerca Sant Joan de Déu Barcelona Spain

4. 3D Chromatin Organization Josep Carreras Leukaemia Research Institute Barcelona Spain

5. CNAG‐CRG, Centre for Genomic Regulation Barcelona Institute of Science and Technology Barcelona Spain

6. Universitat Pompeu Fabra (UPF) Barcelona Spain

7. Pediatric Cancer Center Barcelona Hospital Sant Joan de Déu Barcelona Barcelona Spain

8. Department of Pathology Hospital Sant Joan de Déu Barcelona Barcelona Spain

9. Department of Plastic Surgery Hospital de la Santa Creu i de Sant Pau Barcelona Spain

10. Department of Dermatology Hospital Sant Joan de Déu Barcelona Spain

11. CIBERONC Instituto de Salud Carlos III Madrid Spain

Funder

Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona

Ministerio de Ciencia e Innovación

Ministerio de Ciencia, Innovación y Universidades

European Regional Development Fund

PTEN Research

Fundación Científica Asociación Española Contra el Cáncer

Fundación BBVA

Worldwide Cancer Research

Uppsala Multidisciplinary Center for Advanced Computational Science

European Commission

Instituto de Salud Carlos III

Xarxa de Bancs de Tumors de Catalunya

Publisher

EMBO

Subject

Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.202115619

Reference65 articles.

1. Akt1/protein kinase B is critical for ischemic and VEGF-mediated angiogenesis

2. ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation

3. Gene Ontology: tool for the unification of biology

4. Clinical report: one year of treatment of Proteus syndrome with miransertib (ARQ 092)

5. PI3K isoforms in cell signalling and vesicle trafficking

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