Ribonucleotide reductase inhibitors suppress SAMHD 1 ara‐ CTP ase activity enhancing cytarabine efficacy

Author:

Rudd Sean G1ORCID,Tsesmetzis Nikolaos2,Sanjiv Kumar1,Paulin Cynthia BJ1,Sandhow Lakshmi3,Kutzner Juliane4,Hed Myrberg Ida2ORCID,Bunten Sarah S4,Axelsson Hanna5ORCID,Zhang Si Min1,Rasti Azita1,Mäkelä Petri1,Coggins Si'Ana A6,Tao Sijia6,Suman Sharda1,Branca Rui M7,Mermelekas Georgios7,Wiita Elisée1,Lee Sun1,Walfridsson Julian3,Schinazi Raymond F6,Kim Baek68,Lehtiö Janne7ORCID,Rassidakis Georgios Z9,Pokrovskaja Tamm Katja9,Warpman‐Berglund Ulrika1,Heyman Mats2,Grandér Dan9,Lehmann Sören310,Lundbäck Thomas511,Qian Hong3,Henter Jan‐Inge212ORCID,Schaller Torsten4ORCID,Helleday Thomas113ORCID,Herold Nikolas212ORCID

Affiliation:

1. Science for Life Laboratory Department of Oncology‐Pathology Karolinska Institutet Stockholm Sweden

2. Childhood Cancer Research Unit Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden

3. Center for Hematology and Regenerative Medicine Department of Medicine Karolinska University Hospital Huddinge Karolinska Institutet Stockholm Sweden

4. Department of Infectious Diseases Virology University Hospital Heidelberg Heidelberg Germany

5. Chemical Biology Consortium Sweden Science for Life Laboratory Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden

6. Department of Pediatrics Emory University School of Medicine Atlanta GA USA

7. Department of Oncology‐Pathology Science for Life Laboratory Karolinska Institutet Stockholm Sweden

8. Department of Pharmacy Kyung‐Hee University Seoul South Korea

9. Department of Oncology‐Pathology Karolinska Institutet Stockholm Sweden

10. Department of Medical Sciences Uppsala University Uppsala Sweden

11. Mechanistic Biology & Profiling Discovery Sciences R&D AstraZeneca Gothenburg Sweden

12. Paediatric Oncology Theme of Children's Health Karolinska University Hospital Solna Stockholm Sweden

13. Weston Park Cancer Centre Department of Oncology and Metabolism University of Sheffield Sheffield UK

Funder

Barncancerfonden

Cancerfonden

Svenska Läkaresällskapet

Stiftelsen Clas Groschinskys Minnesfond

Harald och Greta Jeanssons Stiftelse

Åke Wiberg Stiftelse

Stiftelsen Lars Hiertas Minne

Stiftelsen Sigurd and Elsa Goljes Minne

Vetenskapsrådet

Radiumhemmets Forskningsfonder

Ragnar Söderbergs stiftelse

Stockholms Läns Landsting

Stiftelsen Felix Mindus Bidrag till Leukemiforskningen

Loo och Hans Ostermans Stiftelse för Medicinsk Forskning

Märta och Gunnar V. Philipsons Stiftelse

Karolinska Institutet

National Institutes of Health

Torsten Söderbergs Stiftelse

Alex och Eva Wallströms Stiftelse för Vetenskaplig Forskning och Utbildning

Deutsche Forschungsgemeinschaft

Publisher

EMBO

Subject

Molecular Medicine

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