Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity-Reference-Cited by-同舟云学术

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Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity

Published:2018-10-02 Issue:12 Volume:19 Page:
ISSN:1469-221X
Container-title:EMBO reports
language:en
Short-container-title:EMBO Rep

Author:

Basler Michael¹²^ORCID,Lindstrom Michelle M³,LaStant Jacob J³,Bradshaw J Michael³,Owens Timothy D³,Schmidt Christian²⁴^ORCID,Maurits Elmer⁵,Tsu Christopher⁶,Overkleeft Herman S⁵,Kirk Christopher J⁷,Langrish Claire L³,Groettrup Marcus¹²^ORCID

Affiliation:

1. Biotechnology Institute Thurgau (BITg) at the University of Konstanz Kreuzlingen Switzerland

2. Division of Immunology Department of Biology University of Konstanz Konstanz Germany

3. Principia Biopharma South San Francisco CA USA

4. Konstanz Research School Chemical Biology (KoRS‐CB) University of Konstanz Konstanz Germany

5. Leiden Institute of Chemistry Leiden University Leiden The Netherlands

6. Takeda Pharmaceuticals International Co. Cambridge MA USA

7. Kezar Life Sciences South San Francisco CA USA

Funder

Jubiläumsstiftung der Schweizerischen Lebensversicherungs- und Rentenanstalt für Volksgesundheit und medizinische Forschung

Deutsche Forschungsgemeinschaft

Krebsliga Schweiz

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embr.201846512

Reference44 articles.

1. Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

2. Proteasome inhibitors in cancer therapy

3. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

4. Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis

5. Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice

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1. Optimization of α-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 (β5i)/LMP2 (β1i) dual inhibitor;Bioorganic & Medicinal Chemistry;2024-07

2. Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice;Arteriosclerosis, Thrombosis, and Vascular Biology;2024-06

3. Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31;Cells;2024-04-13

4. Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function;European Journal of Immunology;2024-03-08

5. Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits;PLOS Biology;2024-03-06

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