NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss

Author:

Morganti Claudia123ORCID,Ito Kyoko123,Yanase Chie123,Verma Amit345,Teruya‐Feldstein Julie67,Ito Keisuke1235ORCID

Affiliation:

1. Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research Albert Einstein College of Medicine Bronx NY USA

2. Departments of Cell Biology and Stem Cell Institute Albert Einstein College of Medicine Bronx NY USA

3. Department of Medicine Montefiore Medical Center Albert Einstein College of Medicine Bronx NY USA

4. Department of Developmental and Molecular Biology Albert Einstein College of Medicine Bronx NY USA

5. Albert Einstein Cancer Center and Diabetes Research Center Albert Einstein College of Medicine Bronx NY USA

6. Department of Pathology Icahn School of Medicine Mount Sinai New York NY USA

7. Department of Pathology Sloan‐Kettering Institute Memorial Sloan‐Kettering Cancer Center New York NY USA

Funder

National Heart, Lung, and Blood Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Division of Cancer Epidemiology and Genetics, National Cancer Institute

New York State Department of Health

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

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