Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

Author:

Caiado Francisco12ORCID,Pietras Eric M.3ORCID,Manz Markus G.12ORCID

Affiliation:

1. Department of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland

2. University of Zürich, Comprehensive Cancer Center Zürich, Zürich, Switzerland

3. Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO

Abstract

Inflammation is an evolutionarily selected defense response to infection or tissue damage that involves activation and consumption of immune cells in order to reestablish and maintain organismal integrity. In this process, hematopoietic stem cells (HSCs) are themselves exposed to inflammatory cues and via proliferation and differentiation, replace mature immune cells in a demand-adapted fashion. Here, we review how major sources of systemic inflammation act on and subsequently shape HSC fate and function. We highlight how lifelong inflammatory exposure contributes to HSC inflamm-aging and selection of premalignant HSC clones. Finally, we explore emerging areas of interest and open questions remaining in the field.

Funder

National Institutes of Health

Cleo Meador and George Ryland Scott Endowed Chair in Hematology

Comprehensive Cancer Center Zurich

Swiss National Science Foundation

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

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