HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations

Author:

Fazal Raheem12ORCID,Boeynaems Steven3,Swijsen Ann12,De Decker Mathias12,Fumagalli Laura12,Moisse Matthieu12,Vanneste Joni12,Guo Wenting124,Boon Ruben4ORCID,Vercruysse Thomas5,Eggermont Kristel12,Swinnen Bart126,Beckers Jimmy12,Pakravan Donya12,Vandoorne Tijs12ORCID,Vanden Berghe Pieter7,Verfaillie Catherine4,Van Den Bosch Ludo12ORCID,Van Damme Philip126ORCID

Affiliation:

1. Department of Neurosciences, Experimental Neurology Leuven Brain Institute (LBI) KU Leuven – University of Leuven Leuven Belgium

2. Center for Brain & Disease Research Laboratory of Neurobiology VIB Leuven Belgium

3. Department of Genetics Stanford University School of Medicine Stanford CA USA

4. Stem Cell Institute Department of Development and Regeneration Stem Cell Biology and Embryology KU Leuven Leuven Belgium

5. Department of Microbiology, Immunology and Transplantation Laboratory of Virology and Chemotherapy Rega Institute for Medical Research KU Leuven Leuven Belgium

6. Department of Neurology University Hospitals Leuven Leuven Belgium

7. Department of Chronic Diseases, Metabolism and Ageing Translational Research in GastroIntestinal Disorders, KU Leuven Leuven Belgium

Funder

Onderzoeksraad, KU Leuven

Universitaire Ziekenhuizen Leuven, KU Leuven

Alzheimer's Research Foundation

Fonds Wetenschappelijk Onderzoek

Agentschap voor Innovatie door Wetenschap en Technologie

Target ALS

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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