Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins-Reference-Cited by-同舟云学术

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Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins

Published:2020-03 Issue:3 Volume:14 Page:390-405
ISSN:2213-6711
Container-title:Stem Cell Reports
language:en
Short-container-title:Stem Cell Reports

Author:

Abo-Rady Masin,Kalmbach Norman,Pal Arun,Schludi Carina,Janosch Antje,Richter Tanja,Freitag Petra,Bickle Marc,Kahlert Anne-Karin,Petri Susanne,Stefanov Stefan,Glass Hannes,Staege Selma,Just Walter,Bhatnagar Rajat,Edbauer Dieter,Hermann Andreas,Wegner Florian,Sterneckert Jared L.

Funder

DFG

European Union's Horizon 2020

Bundesministerium für Bildung und Forschung

JPND

Ministry of Health, Italy

Ministero dell’Istruzione, dell’Università e della Ricerca

Swedish Research Council

Swiss National Science Foundation

Robert Packard Center for ALS Research

Petermax-Müller-Stiftung

NOMIS Foundation

Helmholtz Virtual Institute

FTD

BIOCREA

Stiftung zur Förderung der Hochschulmedizin

Hermann und Lilly Schilling-Stiftung für medizinische Forschung im Stifterverband

CRTD

Publisher

Elsevier BV

Subject

Cell Biology,Developmental Biology,Genetics,Biochemistry

Reference33 articles.

1. Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressive SOD1 ALS;Benatar;Neurology,2018

2. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits;Chew;Science,2015

3. A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy;Chitiprolu;Nat. Commun.,2018

4. Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis;Ciura;Ann. Neurol.,2013

5. Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability;Devlin;Nat. Commun.,2015

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1. Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets;Frontiers in Cellular Neuroscience;2024-01-19

2. Neural Differentiation and spinal cord organoid generation from induced pluripotent stem cells (iPSCs) for ALS modelling and inflammatory screening;Molecular Neurobiology;2023-12-21

3. Analyzing ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets;2023-11-17

4. A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons;Acta Neuropathologica Communications;2023-09-18

5. iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons;Cell Reports;2023-09

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