Subunit composition of VRAC channels determines substrate specificity and cellular resistance to P t‐based anti‐cancer drugs-Reference-Cited by-同舟云学术

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to P t‐based anti‐cancer drugs

Published:2015-11-03 Issue:24 Volume:34 Page:2993-3008
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Planells‐Cases Rosa¹,Lutter Darius¹,Guyader Charlotte²,Gerhards Nora M³,Ullrich Florian¹,Elger Deborah A¹,Kucukosmanoglu Asli⁴,Xu Guotai⁴,Voss Felizia K¹,Reincke S Momsen¹,Stauber Tobias¹,Blomen Vincent A⁵,Vis Daniel J⁶,Wessels Lodewyk F⁶,Brummelkamp Thijn R⁵,Borst Piet²,Rottenberg Sven³⁴,Jentsch Thomas J¹⁷

Affiliation:

1. Leibniz‐Institut für Molekulare Pharmakologie (FMP) Max‐Delbrück‐Centrum für Molekulare Medizin (MDC) Berlin Germany

2. Division of Molecular Oncology The Netherlands Cancer Institute Amsterdam The Netherlands

3. Institute of Animal Pathology Vetsuisse Faculty University of Bern Bern Switzerland

4. Division of Molecular Pathology The Netherlands Cancer Institute Amsterdam The Netherlands

5. Division of Biochemistry The Netherlands Cancer Institute Amsterdam The Netherlands

6. Division of Molecular Carcinogenesis The Netherlands Cancer Institute Amsterdam The Netherlands

7. NeuroCure Cluster of Excellence Charité Universitätsmedizin Berlin Germany

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201592409

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1. LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication

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3. Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA

4. Does resistance to apoptosis affect clinical response to antitumor drugs?

5. How do real tumors become resistant to cisplatin?

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