The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2

Author:

de Tassigny Alexandra d'Anglemont1234,Berdeaux Alain1234,Souktani Rachid2,Henry Patrick5,Ghaleh Bijan1234

Affiliation:

1. INSERM; U841 Equipe 3 Créteil F-94010 France

2. Université Paris 12, Faculté de Médecine, Institut Mondor de Médecine Moléculaire (IFR 10); Créteil F-94010 France

3. Ecole Nationale Vétérinaire d'Alfort; Maisons-Alfort F-94700 France

4. Fédération de Cardiologie, Groupe Hospitalier Albert Chenevier - Henri Mondor; Créteil F-94010 France

5. Service de Cardiologie, Hôpital Lariboisièe and INSERM U572; 75010 Paris France

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

Reference34 articles.

1. Doxorubicin cardiotoxicity: analysis of prevailing hypotheses;Olson;Faseb J,1990

2. Doxorubicin treatment in vivo causes cytochrome c release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2: Bax ratio;Childs;Cancer Res,2002

3. Anthracycline-induced cardiomyopathy;Keefe;Semin Oncol,2001

4. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity;Minotti;Pharmacol Rev,2004

5. Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis;Arola;Cancer Res,2000

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