Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide

Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates

Published:2022-12-09 Issue:7 Volume:42 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Pettmann Johannes¹^ORCID,Awada Lama²^ORCID,Różycki Bartosz³^ORCID,Huhn Anna¹,Faour Sara²,Kutuzov Mikhail¹^ORCID,Limozin Laurent²,Weikl Thomas R⁴^ORCID,van der Merwe P Anton¹^ORCID,Robert Philippe²⁵^ORCID,Dushek Omer¹^ORCID

Affiliation:

1. Sir William Dunn School of Pathology University of Oxford Oxford UK

2. Laboratoire Adhesion et Inflammation Aix Marseille University UM 61, INSERM UMRS 1067, CNRS UMR 7333 Marseille France

3. Institute of Physics Polish Academy of Sciences Warsaw Poland

4. Max Planck Institute of Colloids and Interfaces Potsdam Germany

5. Assistance Publique‐Hôpitaux de Marseille Marseille France

Funder

Wellcome Trust

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2022111841

Reference52 articles.

1. Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

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4. BurtonJ Siller‐FarfánJA PettmannJ SalzerB KutuzovM van derMerwePA DushekO(2021)Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors.bioRxivhttps://doi.org/10.1101/2021.10.26.465853[PREPRINT]

5. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells

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