A dysregulated acetyl/ SUMO switch of FXR promotes hepatic inflammation in obesity-Reference-Cited by-同舟云学术

A dysregulated acetyl/ SUMO switch of FXR promotes hepatic inflammation in obesity

Published:2014-11-25 Issue:2 Volume:34 Page:184-199
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Kim Dong‐Hyun¹,Xiao Zhen²,Kwon Sanghoon¹,Sun Xiaoxiao³,Ryerson Daniel¹,Tkac David¹,Ma Ping³,Wu Shwu‐Yuan⁴,Chiang Cheng‐Ming⁴,Zhou Edward⁵,Xu H Eric⁵,Palvimo Jorma J⁶,Chen Lin‐Feng⁷,Kemper Byron¹,Kemper Jongsook Kim¹

Affiliation:

1. Department of Molecular and Integrative Physiology University of Illinois at Urbana‐Champaign Urbana IL USA

2. Laboratory of Proteomics and Analytical Technologies Advanced Technology Program SAIC‐Frederick, Inc. National Cancer Institute‐Frederick Frederick MD USA

3. Department of Statistics University of Georgia Athens GA USA

4. Simmons Comprehensive Cancer Center Departments of Biochemistry and Pharmacology University of Texas, Southwestern Medical Center Dallas TX USA

5. Laboratory of Structure Sciences Van Andel Research Institute Grand Rapids MI USA

6. Institute of Biomedicine University of Eastern Finland Kuopio Finland

7. Department of Biochemistry University of Illinois Urbana IL USA

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201489527

Reference47 articles.

1. SUMOylation of the Farnesoid X Receptor (FXR) Regulates the Expression of FXR Target Genes

2. Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice

3. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

4. On Acetyl-CoA as a Gauge of Cellular Metabolic State

5. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

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