Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm3312.pdf
Reference119 articles.
1. Glass, C. K. & Rosenfeld, M. G. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14, 121–141 (2000).
2. Keller, H. et al. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc. Natl Acad. Sci. USA 90, 2160–2164 (1993).
3. Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R. & Mangelsdorf, D. J. An oxysterol signalling pathway mediated by the nuclear receptor LXRα. Nature 383, 728–731 (1996). This study identified oxysterols as endogenous ligands for LXR.
4. Parks, D. J. et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 284, 1365–1368 (1999). The first demonstration that bile acids are endogenous ligands for FXR.
5. Zelcer, N. & Tontonoz, P. Liver X receptors as integrators of metabolic and inflammatory signalling. J. Clin. Invest. 116, 607–614 (2006).
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