Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti‐tumor activity in vivo-Reference-Cited by-同舟云学术

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Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti‐tumor activity in vivo

Published:2021-04-15 Issue:11 Volume:40 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Khazen Roxana¹,Cazaux Marine¹²,Lemaître Fabrice¹,Corre Beatrice¹,Garcia Zacarias¹,Bousso Philippe¹^ORCID

Affiliation:

1. Dynamics of Immune Responses Unit Institut Pasteur, Equipe Labellisée Ligue Contre le Cancer INSERM U1223 Paris France

2. Université de Paris Paris France

Funder

FP7 Ideas: European Research Council

Institut Pasteur

Institut National de la Santé et de la Recherche Médicale

Fondation ARC pour la Recherche sur le Cancer

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2020106658

Reference35 articles.

1. Mechanical Communication at the Immunological Synapse

2. Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data

3. An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse

4. Optogenetic manipulation of calcium signals in single T cells in vivo

5. Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine

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