NKG2D discriminates diverse ligands through selectively mechano‐regulated ligand conformational changes

Author:

Fan Juan1,Shi Jiawei2,Zhang Yong34ORCID,Liu Junwei25,An Chenyi1,Zhu Huaying1,Wu Peng1,Hu Wei1,Qin Rui1,Yao Danmei1,Shou Xin6,Xu Yibing6,Tong Zhou7,Wen Xue8,Xu Jianpo9,Zhang Jin91011,Fang Weijia7,Lou Jizhong34,Yin Weiwei21213,Chen Wei1251014ORCID

Affiliation:

1. Department of Cell Biology and Department of Cardiology of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China

2. Key Laboratory for Biomedical Engineering of the Ministry of Education Zhejiang University Hangzhou China

3. Key Laboratory of RNA Biology CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing China

4. University of Chinese Academy of Sciences Beijing China

5. Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision Medicine Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou China

6. Institute of Translational Medicine School of Medicine Zhejiang University Hangzhou China

7. Department of Medical Oncology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China

8. Department of Pathology The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China

9. Center for Stem Cell and Regenerative Medicine Department of Basic Medical Sciences The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China

10. Zhejiang Laboratory for Systems and Precision Medicine Zhejiang University Medical Center Hangzhou China

11. Institute of Hematology Zhejiang University Hangzhou China

12. Department of Thoracic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China

13. Zhejiang Provincial Key Laboratory of Cardio‐Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal College of Biomedical Engineering and Instrument of Science Zhejiang University Hangzhou China

14. The MOE Frontier Science Center for Brain Science & Brain‐machine Integration Zhejiang University Hangzhou China

Funder

Natural Science Foundation of Zhejiang Province

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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