Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors

Author:

Wang Xuesong1,Ray Rashmi1,Kratochvil Sven1,Melzi Eleonora1ORCID,Lin Ying‐Cing1,Giguere Sophie1,Xu Liling1,Warner John1,Cheon Diane1,Liguori Alessia234,Groschel Bettina234,Phelps Nicole234,Adachi Yumiko234,Tingle Ryan234,Wu Lin5,Crotty Shane467,Kirsch Kathrin H1ORCID,Nair Usha1ORCID,Schief William R1234ORCID,Batista Facundo D189ORCID

Affiliation:

1. The Ragon Institute of Massachusetts General Hospital Massachusetts Institute of Technology and Harvard University Cambridge MA USA

2. Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA USA

3. IAVI Neutralizing Antibody CenterThe Scripps Research Institute La Jolla CA USA

4. Consortium for HIV/AIDS Vaccine Development (CHAVD) The Scripps Research Institute La Jolla CA USA

5. Genome Modification Facility Department of Molecular and Cellular Biology Harvard University Cambridge MA USA

6. Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology (LJI) La Jolla CA USA

7. Department of Medicine University of California, San Diego La Jolla CA USA

8. Department of Immunology Harvard Medical School Boston MA USA

9. Department of Microbiology Harvard Medical School Boston MA USA

Funder

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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