C‐terminal deletion‐induced condensation sequesters AID from IgH targets in immunodeficiency-Reference-Cited by-同舟云学术

C‐terminal deletion‐induced condensation sequesters AID from IgH targets in immunodeficiency

Published:2022-04-26 Issue:11 Volume:41 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Xie Xia¹^ORCID,Gan Tingting²^ORCID,Rao Bing¹^ORCID,Zhang Weiwei²,Panchakshari Rohit A³⁴,Yang Dingpeng¹,Ji Xiong²,Cao Yu⁵^ORCID,Alt Frederick W³⁴^ORCID,Meng Fei‐Long¹^ORCID,Hu Jiazhi²^ORCID

Affiliation:

1. State Key Laboratory of Molecular Biology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai China

2. The MOE Key Laboratory of Cell Proliferation and Differentiation Genome Editing Research Center School of Life Sciences Peking‐Tsinghua Center for Life Sciences Peking University Beijing China

3. Program in Cellular and Molecular Medicine Howard Hughes Medical Institute Boston Children’s Hospital Boston MA USA

4. Department of Genetics Harvard Medical School Boston MA USA

5. Shanghai Institute of Precision Medicine Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2021109324

Reference57 articles.

1. DNA/RNA hybrid substrates modulate the catalytic activity of purified AID

2. Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

3. Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

4. C-Terminal Deletion of AID Uncouples Class Switch Recombination from Somatic Hypermutation and Gene Conversion

5. Evolution of Phosphorylation-Dependent Regulation of Activation-Induced Cytidine Deaminase

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1. RNA 2'-O-methylation promotes persistent R-loop formation and AID-mediated IgH class switch recombination;BMC Biology;2024-07-08

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3. Heterologous booster vaccination enhances antibody responses to SARS-CoV-2 by improving Tfh function and increasing B-cell clonotype SHM frequency;Frontiers in Immunology;2024-06-21

4. Mechanism and Regulation of Immunoglobulin Class Switch Recombination;Molecular Biology of B Cells;2024

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