Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor-Reference-Cited by-同舟云学术

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

Published:2021-05 Issue:11 Volume:40 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Tan Michele S Y¹^ORCID,Koussis Konstantinos¹,Withers‐Martinez Chrislaine¹,Howell Steven A²,Thomas James A³^ORCID,Hackett Fiona¹,Knuepfer Ellen⁴,Shen Min⁵,Hall Matthew D⁵,Snijders Ambrosius P²,Blackman Michael J¹³^ORCID

Affiliation:

1. Malaria Biochemistry Laboratory The Francis Crick Institute London UK

2. Protein Analysis and Proteomics Platform The Francis Crick Institute London UK

3. Faculty of Infectious and Tropical Diseases London School of Hygiene & Tropical Medicine London UK

4. Department of Pathobiology and Population Sciences Royal Veterinary College Hertfordshire UK

5. National Center for Advancing Translational Sciences (NCATS) National Institutes of Health Rockville MD USA

Funder

Cancer Research UK

Medical Research Council

National Center for Advancing Translational Sciences

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2020107226

Reference53 articles.

1. A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts

2. Dengue 2 Virus NS2B and NS3 Form a Stable Complex That Can Cleave NS3 within the Helicase Domain

3. Clues to Evolution of the SERA Multigene Family in 18 Plasmodium Species

4. A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

5. Processing of thePlasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion

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