Affiliation:
1. Molecular Parasitology Humboldt University Berlin Berlin Germany
2. Centre for Structural Systems Biology Hamburg Germany
3. Bernhard Nocht Institute for Tropical Medicine Hamburg Germany
4. University of Hamburg Hamburg Germany
Abstract
AbstractAn essential step in the life cycle of malaria parasites is their egress from hepatocytes, which enables the transition from the asymptomatic liver stage to the pathogenic blood stage of infection. To exit the liver, Plasmodium parasites first disrupt the parasitophorous vacuole membrane that surrounds them during their intracellular replication. Subsequently, parasite‐filled structures called merosomes emerge from the infected cell. Shrouded by host plasma membrane, like in a Trojan horse, parasites enter the vasculature undetected by the host immune system and travel to the lung where merosomes rupture, parasites are released, and the blood infection stage begins. This complex, multi‐step process must be carefully orchestrated by the parasite and requires extensive manipulation of the infected host cell. This review aims to outline the known signaling pathways that trigger exit, highlight Plasmodium proteins that contribute to the release of liver‐stage merozoites, and summarize the accompanying changes to the hepatic host cell.
Subject
Molecular Biology,Microbiology
Cited by
1 articles.
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